.an infiltration is an inadvertent administration of a nonvesicant into the surrounding tissue. This is based on results in animals with other known arteriolar irritants. Le A, Patel S. Extravasation of noncytotoxic drugs: A review of the literature. Another long-term effect is complex regional pain syndrome, a neurologic syndrome that … Infiltration and extravasation can be caused by mechani-cal, physiologic, or pharmacologic factors (Table 1). 1999; 56:1742-3. Extravasation injury from cancer chemotherapy is reported to be 11% in children and 22% in adults.3 Jacobs reported a rate of 0.6% (41 events out of 6,600 injections) for extravasation of contrast agents given with high-pressure injector pumps.4 Although pumps do not cause infiltration or extravasation, their use forces fluid into the subcuta- But, Infiltration and Extravasation of fluids into the tissue can often lead to tissue damage at the site of the leakage from the vein. ". 2014 Apr 8;48(7):870‐886. Both infiltration and extravasation can have serious consequences: the patient may need surgical intervention resulting in large scars, experience limitation of function, or even require amputation. Unless a large volume is infused into the tissue, an infiltration usually resolves relatively quickly without major sequelae. How common is this complication and can it be reduced? management of (extravasation) after it occurs, although sympathetic block and heparinization are commonly employed during acute management”. [infiltration most often occurs as a result of dislodging of the iv cannula.] According to a recent publication by Ozalp et al (1), who inserted 297 catheters in 173 children, Infiltration occurred in 2.9% of the patients and extravasation occurred in 2.3% of the patients. The effects are sometimes devastating because of the volume involved and because these devices are more likely to be delivering vesicant medications. A look at the differences of infiltration and extravasation. vesicants cause blistering, severe tissue damage, and even necrosis if extravasated. . A case study report entitled “Extravasation of i.v. Mechanical factors, occurring either during initial catheter insertion or while the catheter is in place, 2,8 and physiolog-ic factors relating to preexisting or emerging vein 3. extravasation is defined as an inadvertent delivery of a vesicant into the tissues. promethazine” can be found in Am J Health-Syst Pharm. Although infiltration and extravasation are more likely to occur with peripheral I.V. infusions, these complications can develop with central venous catheters and implanted infusion ports as well. An infiltration is defined as the inadvertent infusion of a medication or solution into the surrounding tissue rather than into the intended vascular system. Ann Pharmacother.

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